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The Department of Pharmacology was founded in 1945. Associate Professor S. Lealicov was the first head of the department (1945-1948). He was succeeded by N. Harauzov, Associate Professor, who was the rector of Chisinau State Institute of Medicine (CSIM) during the same period (1948-1951).  In 1951–1952 the Department was headed by the famous scientist and educator A. Zubcov.  Associate Professor M. Ter-Stepanov (1952-1958), university professor V. Chernov (1958-1961), Associate Professor S. Lealicov (1961-1966), Associate Professor Matcovski C. (1966 – 1968) and university professor  E. Muhin (1968-1988) also fronted the department.

In 1980, by Rector’s order No. УП-130 of 15.12.1979, the Clinical Pharmacology course was set up at CSIM. In 1982, by order of the MSSR Ministry of Health No. 703 of 19.10.1982, in connection with the inclusion of the Clinical Pharmacology discipline in the curricula of medical institutions, the Department of Clinical Pharmacology was established.

In October 1988, the Department of Pharmacology and the Department of Clinical Pharmacology were merged.

Employees of the department work at the following clinical bases: Republican Clinical Hospital public health institution, Municipal Clinical Hospital No. 1 public health institution, V. Ignatenco Municipal Hospital for Children public health institution,  Hospital of Ministry of Health public health institution (Gastroenterology Unit),  National Scientific and Practical Center for Emergency Medicine public health institution  (Neurosurgery Unit No.1),  Sf. Arhanghel Mihail Municipal Hospital public health institution (Therapy Unit),  Oncological Institute public health institution, Institute of Neurology and Neurosurgery public health institution.

The training of clinical pharmacologists begins in 1999, with the issuance of the Order On the approval of the regulation and the inclusion of pharmacologist-clinician specialty. According to Order of the Ministry of Health of the Republic of Moldova No. 493 of 22.05.2012, the Clinical Pharmacology Service is implemented in the Public Health Institution (curative) in the Republic of Moldova.

The basic objectives of the service are as follows: 

- rational use of drugs, 

- ensuring rational purchase of drugs, 

- information service, 

- interdepartmental pharmacotherapy quality control, prevention of pharmacotherapy complications, 

- detection, control and treatment of adverse effects of medications – pharmacovigilance; 

- development of regulatory guidelines for quality improvement by enhancing the efficiency and safety of treatment while using medicinal  preparations; 

- pharmacoeconomics - analysis of the cost (costs) and results of drug use, i.e. drug cost-effectiveness;

- pharmacoepidemiology - surveillance of contraindications and precautions of diseases of medicinal etiology;

- Clinical evaluation of new drugs based on GCP.

Scientific activity.

The department’s major research subject is Development of new local drugs and optimization of pharmacotherapy in some pathological conditions

The main directions of research are the following:

- Experimental and clinical study of new drug substances with antihypertensive and antihypotensive action;

- pharmacological study of new adsorbents in various pathological conditions and intoxications;

- study of medicinal substances of vegetal and entomological origin;

- study, optimization and individualization of pharmacotherapy of diseases and pathological conditions;

- study of drug interaction, etc.

The Department has developed and proposed for clinical use the following drug preparations: Izoturon, Difetur, Regesan, Nucina, Medicas E, Carbosem, Olizin, Profetur, Metiferon, Benzituron, Entoheptin, Imupurin, Imuheptin, Adenoprosin, Doresan, Nucosan, Dovisan, Raviten, Ravimig, Raviset.

E-mail: farmacologieclinica@usmf.md

Tel. 73-38-05, 205 412, Fax. 73-38-05